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Back in 1899 Thomas Barlow had already summarized with great element the distinction between erythromelalgia and Raynaud's disease as following: Dependence produces considerable increase of the dusky red or violaceous tint of the extremity affected; the arteries on this place of the limb might pulsate forcibly; ache is frequent, typically fixed, and more especially when the limb depends or components pressed upon; in wintry weather, or on the applying of cold, the situations are relieved; then again, warmth and summer weather will increase pain; there is no lack of sensation, but there could also be increased sensitiveness; the native temperature of the affected components may be raised or lowered; gangrene does not happen; the affection is asymmetrical; there's a certain amount of swelling, sometimes allowing pitting on strain, sometimes not; incisions over such swelling, even down to the bone, have proved useless; excessive ache on pressure upon the nerves supplying the elements affected is just not discovered; muscular wasting is discovered, but explainable by the disuse of the limb, and is not at all as extreme as in cases of disease of the peripheral nerves; a reaction of degeneration within the nerves of the affected components has not been found; the deep reflexes, with few exceptions, aren't decreased. 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