Well Differentiated Papillary Mesothelioma TreatmentWell differentiated papillary mesothelioma is found typically in the lining of the abdomen, called the peritoneum. It can also be found in lung pleura and the tunica vaginalis in the testes.The aggressive nature of mesothelioma can be treated and is generally successful. However, it is possible for it to be recurrent and can develop into more advanced forms of cancer.SymptomsPapillary mesothelioma which is well differentiated is found on the membranes that surround different organs. It is usually located in the peritoneum. However, it can be found on the Pleurae (lining of the lung) and the pericardiums (a sac that surrounds the heart), and tunica vaginaliss (the tissue that surrounds the testicles). Certain mesothelioma types are benign, while the majority are cancerous. They are known as low-grade mesothelioma that typically has a better prognosis than mesothelioma that is malignant.Asbestos exposure is a major cause mesothelioma. In certain cases, asbestos exposure can cause symptoms that appear years later. Doctors must conduct a physical exam and collect blood samples for laboratory tests to diagnose the condition. They also make use of imaging technology, such as x-rays, MRIs and PET scans to determine symptoms of mesothelioma.The treatment of mesothelioma is the most effective when the tumors are treated and detected in the early stages, before they develop into malignant forms. So, many mesothelioma experts recommend routine follow-ups to detect any potential changes. However an investigation published in the Journal of Medical Ultrasound showed that regular imaging follow-ups might not be required for patients with well differentiated papillary mesothelioma.The report analyzed the first instance of WDPM that was found to be concurrently associated with a struma ovarii which is a rare tumor found in the serosal tissue around the uterus. The patient had abdominal pain that was accompanied by symptomatic debulking laparoscopy. The pathology that resulted revealed a non-invasive papillary growth of mesothelial cells that retained the BAP1 marker. BAP1 - considered desirable under the latest WHO classification.According to the study, WDPM is considered an indolent tumor and is rarely transformed into an mesothelioma that has invasive properties. The researchers of the study have noted that invasive epithelioid mesotheliomas that are not ambiguous may also mimic WDPM.DiagnosisIn many cases, abdominal pain or swelling are the first symptoms. The fluid can accumulate in the abdomen or in the lungs. It is important to get an accurate diagnosis from a qualified doctor. Mesothelioma is categorized as either epithelial or sarcomatoid and some tumors are biphasic (a combination of both types). Contrary to malignant mesothelioma which can develop rapidly and spread to other areas of the body, WDPM is typically benign.The majority of mesotheliomas can be classified based on their cell type. The most common is epithelial, and the most rare is sarcomatoid. But a few studies have examined the possibility that mesothelioma could evolve into a well-differentiated, mesothelioma papillary. Sarcomatoid cancer is an unfavorable prognosis, mesothelioma that is considered to be low risk.Up until recently there were just 14 cases of well-differentiated papillary mesothelioma reported in the medical literature. The rare tumor is found in the lining of specific organs, such as the peritoneum and the pleura. The exact cause is not known, but it is believed that exposure to asbestos is the primary cause.The WDPM tumor develops in the tissues of the organ it attacks, typically the peritoneum. It can also develop in the pleura sac that surrounds the lungs, and the tunica vaginalis in the tests.WDPM is considered mesothelioma of low grade, but it has the potential to develop into malignant mesothelioma over time. Some patients have developed both mesothelioma that is malignant and WDPM in the same place in their bodies.Doctors diagnose WDPM by using the tissue sample of the affected. They then perform laboratory tests on the sample. These tests check for the presence of cancer cells and the degree of differentiation of those cells. If a patient is diagnosed with this disorder and is diagnosed with it, they should attend regular follow up appointments to make sure that the tumor doesn't expand or become recurrent. WDPM could be misdiagnosed as a different condition or misinterpreted as benign mesothelioma, so it is essential that doctors are aware of the rare nature of this tumor and the possibility of it recurring. If you have a repeat of this condition should discuss their options with an experienced mesothelioma lawyer.TreatmentWell differentiated papillary mesothelioma treatment is generally successful and usually leads to a better prognosis than other mesothelioma types. Similar to other mesothelioma types, patients must consult an expert for the correct diagnosis and receive the most effective treatment.The first step of mesothelioma treatment is to remove the cancerous tissue or tumor from the body area affected. The surgeon may also use chemotherapy or radiation therapy to kill any remaining cells and stop the development of new cancerous tumors in the future.The majority of mesothelioma cases occur in the the abdominal cavity however, doctors have also observed it in other areas of the body as well as the pleura (lung liner) and the pericardium (heart sac) and tunica vaginalis (tunicles). In the case of WDPMT the tumors usually appear as nodules that are white to gray that are about one to three centimeters in diameter. The tumors grow slowly however, they can cause lots of swelling and pain when they expand.The cell structure of a well-differentiated mesothelioma papillary is distinctive and distinguishes it from other types of mesothelioma. The tumors have a branching pattern of bland cuboidal mesothelial cells that form finger-like projections called papillae. The papillae typically are located in the lining of the peritoneum however, they can also be found in the pleura as well as testicles.WDPM, epithelial types of mesothelioma, and other cellular structures must be distinguished from malignant sarcomatoid, mesothelioma. This type of cancer is more aggressive. Sarcomatoid cells of mesothelioma are more likely than others to expand quickly and spread throughout the body.Sarcomatoid Mesothelioma, on the contrary is more likely be associated with smoking than asbestos exposure. Nonetheless, the connection between mesothelioma and asbestos remains undetermined. Asbestos may cause the development of malignant and benign forms of mesothelioma. However, it does not appear to be the cause of WDPM. WDPM that is solitary can progress into mesothelioma that is malignant. It is not clear which patients are at the most risk. There is a higher likelihood of having a more aggressive course of action for those who's solitary WDPM is deficient in the BAP1 and the MTAP.The following is a list of preventions.Papillary mesothelioma occurs most frequently in the abdomen's lining (peritoneum) and less commonly in the linings of the lungs and testicles. This type of epithelial mesothelioma is generally benign and has a favorable prognosis. There is a very small possibility that the cancer may develop into malignant. This cancer is believed by experts to be caused by asbestos, a carcinogen. But, researchers continue to look into possible causes.In a small number of cases, WDPM may transform into mesothelioma that is malignant. This is a rare situation. However, it is important that you seek treatment and diagnosis as quickly as you can if you notice any of the symptoms.WDPM and Sarcomatoid Mesothelioma are two separate types of malignant tumors that differ from one other in their cell structure and prognosis. WDPM is typically epithelial while the sarcomatoid type is more often a sarcomatoid tumor. It is also possible to have a biphasic mesothelioma, that is characterized by both the epithelial and sarcomatoid types.Because mesothelioma advanced treatment is generally benign, this kind of mesothelioma generally has a better prognosis than most other malignancy types. This is particularly relevant when it is found in the peritoneum. However, it may cause serious health issues and is very difficult to treat in the tunica or pleura vaginalis.Typically doctors will diagnose this kind of mesothelioma if it is found during surgery for a different condition or by chance in a patient suffering from abdominal pain and/or fluid accumulation. A biopsy is the only method to confirm the diagnosis.Patients with a history of asbestos exposure should be assessed by a mesothelioma physician who has access to the most recent research and treatment methods. When combined with aggressive locoregional treatment that includes cytoreductive surgery to eliminate all gross disease and hyperthermic intraperitoneal chemotherapy to eliminate any remaining microscopic cancer patients have reported 3 year survival rates of as high as 60%. This is far higher than the average survival rate of the historical controls. Therefore, it is essential to seek care at mesothelioma referral centers.