Mesothelioma - What is Mesothelioma?As with all cancers, mesothelioma develops when mutations occur within the DNA of cells. The mutations cause cells to grow and multiply unchecked, which results in the formation of a tumor.The symptoms of mesothelioma are dependent on the type and location. For instance mesothelioma that is pleural causes fluid buildup in the lining of the chest cavity called pleural effusion.DiagnosisIn the majority of cases mesothelioma is diagnosed when a person sees their family physician. They will inquire about his or her symptoms and perform a physical examination. They may also recommend a number of tests.These tests are used to assess a person's overall health and the performance of their organs. Blood tests can be used to detect specific chemicals that are produced by cells suffering from mesothelioma. X-rays are also beneficial especially for patients with mesothelioma pleural. They can show fluid build-up and a thickening of the pleura. MRI scans are a way to check the abdomen of patients with mesothelioma of the peritoneal region for indications of cancer.The doctor may need to take a small sample of the tissue the area of growth of the cancer which is known as biopsy. The biopsy sample will be sent to a lab for analysis. They will search for mesothelioma tumor cells within the tissue, and also assess how the cells are growing and if they are spreading. The type of mesothelioma that cells possess is vital to the prognosis of mesothelioma. There are three main types: epithelioid (which accounts for 70 percent of diagnoses), and sarcomatoid (20 percent of diagnoses).A surgical biopsy is a way to confirm a mesothelioma diagnosis and determine the stage of the disease. A surgeon will insert a needle in the abdomen or chest wall to remove a small sample of tissue to be tested.Doctors may also remove fluid from the peritoneum or pleura (called a "pleural effusion") to check for mesothelioma. This is typically done using a tube placed down the throat of a person who is sedated known as an endobronchial ultrasound needle biopsy.Other methods of collecting mesothelioma samples include fine needle biopsy and thoracoscopy. In these tests, doctors use imaging scans to guide a camera into the chest or abdomen. They will then take tissue samples and drain them to be examined by pathologists. In certain cases, the GP will also request an in-depth staining of the tissue sample. This test looks for certain molecules that are found only in mesothelioma cell lines and helps distinguish them from non-cancerous or cancerous cells.TreatmentIf mesothelioma is diagnosed doctors will work to remove as much of the cancer as possible. This helps reduce the symptoms and increases the chance of cancer recurrence. Doctors may also consider alternative treatments to slow down the growth of mesothelioma, or stop its spread. These include chemotherapy, surgery and radiation. Doctors can also prescribe medicines to help control nausea, pain and other symptoms.The type of mesothelioma you have determines the treatment options you have. You and your doctor discuss treatment options and how they could affect your life quality. This is called shared decision making, and it's an crucial to the mesothelioma care team process.The pleura is the lining that surrounds the lungs. The pleura protects and surrounds the diaphragm, chest wall, and the lungs. Pleural mesothelioma is distinct from lung cancer which occurs in the lungs.During the procedure, doctors can take a biopsy of the pleural tumor to confirm the diagnosis and determine if it has spread. They can do this by VATS (video assisted thoracoscopic surgical), a type keyhole surgery or by using CT guided needles to collect the pleural tissue for analysis under local anaesthetic.If mesothelioma is not resectable, doctors can drain fluid from the pleura to reduce breathlessness and alleviate pain in the chest. They can also offer an alternative treatment to ease other symptoms, such as fatigue, pain, and loss of appetite.Some patients choose radiotherapy or chemotherapy to shrink the mesothelioma tumor or stop it from spreading. These are the norm of care, however your doctor might suggest different methods of treatment if they believe it can increase your chances of a favorable outcome.Recurrent mesothelioma happens when mesothelioma recurs after treatment. Those with recurrent mesothelioma may benefit from participating in clinical trials for new treatments. Learn more about clinical trials by using our Mesothelioma Research Tool. It shows how mesothelioma treatment trials have helped patients with similar tumours.PrognosisThe outlook of a patient with mesothelioma varies based on the type of cancer as well as the location of the tumor, and whether it has spread beyond its original site. Mesothelioma is classified as epithelial or sarcomatoid biphasic cancers. Mesothelioma patients who have a majority of epithelioid cells tend to live longer than those with more sarcomatoid or biphasic cells.Doctors use imaging tests and a physical examination to determine if a patient has mesothelioma. They also review the patient's medical records and the history of asbestos exposure. The doctor may request a biopsy to obtain a small sample from the tumor or mass to be tested in a laboratory. A biopsy can be done using surgery, needles inserted into the chest or abdomen or by removing fluid from the affected area using the procedure known as thoracentesis.The most frequent mesothelioma-related sites are the peritoneum (the membrane that covers the stomach, intestines, and the liver) or the pericardium (the thin membrane covering the heart). The disease is most commonly seen in men more than women and typically occurs in people who are older than 60 years old. It may take between 30 and 50 years after exposure to asbestos for symptoms to develop.Symptoms of mesothelioma can include difficulty breathing, coughing or abdominal pain. cancer and mesothelioma is a disease in which fluid builds up in the abdomen.After diagnosing mesothelioma, doctors may perform imaging tests to determine if the cancer spreads or to determine if there are other tumors within the body. They can also order blood tests to measure the levels of specific proteins that are more prevalent in mesothelioma patients.In addition to undergoing surgery mesothelioma patients can improve their prognosis by making healthy lifestyle choices, like getting enough sleep and eating a balanced diet. They can also learn how to relax and lessen stress. A strong support network can also help patients manage their illness.The following is a list of preventions.The best way to avoid mesothelioma is to stay clear of asbestos exposure. However there are many who are at risk of developing the disease due to previous exposure. Regular screening can detect asbestos exposure earlier if you have a past history.Mesothelioma is a form of cancer that develops in the tissue lining of organs and structures. It is typically caused by asbestos exposure. The cancer can be found in the abdomen, lungs or heart. There are many types of mesothelioma. The most popular is called pleural mesothelioma. It affects the lung's lining (pleura). It may also affect the abdomen's lining (peritoneum), or testicles (asbestosis).Asbestos is the most common cause of Mesothelioma. Symptoms usually appear 20 years after exposure. People who are most at risk of mesothelioma comprise those who were exposed to asbestos as miners or welders, construction workers or in the automotive industry. People who were exposed to asbestos as a result of their military service could also be at risk for mesothelioma.There are four types of malignant mesothelioma of the pleural. They are classified by the type of cells that create them. They are epithelial, sarcomatoid and biphasic as well as mixed. Each type has its own treatment options.The most common type is malignant pleural Melanoma. It happens when the lung's lining (pleura) develops abnormal cells that multiply and form tumors. Men are more likely to develop it than women.It can be difficult to identify because the symptoms often mimic those of other illnesses or diseases. Coughing, shortness of breath and chest pain could be symptoms. The lungs can be filled with fluid (pleural effusion) and an increase in the size of the lungs called pulmonary edema are also common. Pericardial mesothelioma may be caused by abnormal cells in the pericardium, which lines the heart. Mesothelioma may also develop in the testicles and cause specific symptoms such as pain, a lump in the scrotum, or loss sexual function.Other risk factors include a family background of the disease, a previous cancer diagnosis or genetics. Regular X-rays, blood tests and other tests may help identify asbestos in the lungs, or other signs of lung disease.