Union Pacific Cancer ClusterThe Union Pacific Rail Yard just northeast of downtown Houston is contaminated by chemicals that are connected to a cancer cluster. These chemicals include dioxin and creosote.A study showed that the groundwater and soil around the railyards were contaminated with substantial amounts of the toxins. Researchers have found that residents affected have been diagnosed with a myriad of ailments including skin cancer, prostate cancer and bile duct cancer which is a form of liver cancer.CreosoteCreosote, which is a mix of hundreds of chemicals used to preserve wood and other materials, is a possible carcinogen. In addition to cancer, creosote also believed to cause eye damage and dermatitis.Houston's union pacific cancer cluster is made up of an area that is plagued by creosote. The community has been protesting against the pollution in recent months, and is now demanding that Union Pacific remove the waste.Residents have fought for years for the railroad company to eliminate their pollution. They have not given up, and are now suing the railroad in federal courts, hoping that the company will finally accept responsibility for the contamination.They say that creosote can be an endocrine-depleting substance that has been contaminating their homes and causing them to become ill. They claim that the pollution causes children to develop cancer at a rate five times higher than the rate of national average.The pollution is causing illness and is threatening the lives of residents. The pollution is infiltrating the soil, water, and air of the area.According to the Houston Chronicle creosote was removed from the site by Southern Pacific for many decades before it was bought by Union Pacific in 1997. The company did not take responsibility for the pollution until the last few years, when residents began an effort to eliminate the polluted area.Despite their efforts, people living in the union Pacific cancer cluster continue to suffer from ailments such as Esophagus and lung cancers. Union Pacific Lawsuit Settlements have high rates of childhood lymphoblastic leukemia.While Railroad Workers don't know the exact reason behind the contamination, they suspect that it is caused by the chemicals in creosote. These chemicals have been linked to an increase in risks of esophagus, lung and throat cancers.It is believed that the chemical was used in many ways, including wood preservation and as an anti-ringworm treatment. It is also used in fungicides, insecticides, and other fungicides.Research suggests that the compounds in creosote are subject to an oxidation-reduction reaction that makes them poisonous. This process could lead to biodegradation of the compounds, release of toxic byproducts into soil and water. The process can take a bit of time, and it is only possible in the event that the chemical compound is low enough.DioxinDioxin is one of the chemicals that have been linked to many types of cancers. It is toxic to kidneys, livers and central nervous system.It is found in soil, water, and air. It can also be absorbed through the skin or consumed in food. It is among the "dirty dozen" chemicals.Dioxins with high levels can cause health problems such as cancer and liver problems for those who are exposed to them in industrial accidents or occupational exposure. However, the health consequences of dioxins with low levels are not well understood.The long-term effects of this contaminant remain being studied by researchers. It has been linked with cancer in laboratory animals as well as people who live in areas.According to the World Health Organization (WHO), dioxins have been proven to increase the risk for certain types of cancer . They can also affect the reproductive and immune systems. They can also cause birth defects.Dioxins can be absorbed through many ways, including eating fatty food as well as burning household waste as well as exposure to harmful substances. Other sources of dioxins that are found in the environment include industrial accidents, herbicides and pesticides.If you smoke, you are likely to have higher levels of dioxins compared to other people. You can lower the risk by quitting smoking.Healthy, balanced, nutritious diets are essential, particularly when it is about vegetables, fruits, grains, and other foods. These can reduce or prevent your exposure to dioxins, and their compounds.Healthy eating habits can help you avoid other health problems such as lung cancers and bronchus. In addition, you should avoid eating meat or milk products that have high levels of fat.You can limit your exposure by choosing foods low in fat. It is crucial to eat lots of fresh fruits and vegetables and to drink plenty of water.Dioxin is a toxic chemical that has been linked to many kinds of cancers. This includes breast and liver cancer. It can cause damage to the brain, heart, and lungs.Toxic MetalsMetals such as cadmium, copper, nickel, mercury, chromium and iron are essential for life but can be toxic if they are used in excess. They can also be found in small amounts in sewage as well as other polluting sources, as in electronic waste (ewaste).Numerous environmental heavy metals are linked to various diseases such as cancer. Despite their importance in the development and onset of these diseases however, it isn't known which organ systems.The toxicity of heavy metals varies on the chemical properties of the individual ions and the specific cells that these ions bind to. These interactions include the production of ROS inhibitory enzymes that create compounds that are oxidative and inactivation of other proteins that can protect cells from toxic effects.Alongside these common mechanisms, every metal has its own distinct toxicities. Cadmium and copper for instance, could reduce antioxidant defenses by producing superoxide anionradios (ROS) which harm mitochondrial functions and DNA. Additionally the metals may connect to protein phosphatases (PP) and block glutathione peroxidase.Similar to lead and arsenic, arsenic and arsenic are often linked with an oxidative stress which results in inflammation and lipid peroxidation. These oxidative stresses can cause heart disease, lung cancer and other health problems.This is particularly true for arsenic and lead which may trigger the expression of pro-inflammatory chemokines and microRNAs, which promote the growth of cancerous cells. It is possible that these chemicals interact with genes involved in cell cycle and DNA repair to increase their mutagenic or carcinogenic properties.Another important role of heavy metals is that they increase the risk of developing prostate cancer. This is of great concern as prostate cancer is the most common type of cancer in men and the leading cause of death in the United States.Cadmium and copper also increase the risk of stroke, coronary heart disease and cardiovascular disease. These findings are significant since they reveal the importance of environmental toxic metals in increasing the risk of developing cardiovascular disease. They also play an important role as behavioral factors. However there is a need for more research to better understand the relationships and to determine causality.PesticidesPesticides are chemicals that are used to combat insects and diseases as well as fungi in agriculture (Langley and Mort 2012, Mostafalou and Abdollahi 2017,). They are vital in maintaining the production of agricultural products and provide safe food for the population. However, they may be harmful to the environment as well as human health when absorbed through direct contact with skin , or inhalation.In the United States, the number of pesticides being used is estimated at more than 1.1 billion pounds each year. This is an enormous amount of toxic chemicals which can be inhaled or consumed. The Environmental Protection Agency regulates pesticide use.Although pesticides are commonly applied on many crops, there is a growing concern over their effects on human health as well as the environment. Certain pesticides have been classified by the World Health Organization as potentially carcinogenic, or could cause cancer. Cancer Lawsuits has led to an increase number of research projects to investigate the connection between exposure to pesticides and the health outcomes, such as cancer. These studies employ diverse methods such as multilevel mixed effect models and Cox proportional risks regressions.These methods are commonly used to analyze the connection between a particular chemical and health-related outcome such as cancer at a local, state or national scale. This type of analysis is crucial because it gives a broad view of the possible links between environmental pollutants and health outcomes, allowing for targeted investigation of specific chemicals.Another significant impact of pesticides on health is the potential for exposure through workplace activities that involve the application, transportation and storage of these chemicals. This can be affected by many factors, including the location of the worker as well as the products they use.Pesticides are also absorbed through the skin or inhalation. They may also be present as food. This can be harmful to health, particularly in infants and children.Pesticides, in addition, can affect the air and groundwater and can cause kidney damage and respiratory ailments. The pollutants can be released by a variety of sources, including factories and waste incinerators. Most hazardous are dioxins, which can cause cancer as well as other diseases such as liver disease.